AB0580 Clinical characteristics and risk factors of behcet's patients with conduction disturbances-data from a cardiovascular clinical center in china

Background Behcet9s disease is a kind of systemic vasculitis affecting multiple systems. Although symptomatic cardiac involvement in Behcet9s disease is uncommon, the fatality rate may reach up to 29%. Conduction disturbances might lead to poor outcome and often need permanent pacemaker implanted. The characteristics of conduction disturbances in Behcet9s disease were rarely reported before. Objectives To investigate the clinical characteristics of Behcet9s patients with conduction disturbances and explore the underlying risk factors. Methods We reviewed 57 medical records of Behcet9s disease with cardiovascular lesions in Anzhen Hospital, Capital Medical University between January 2002 and July 2015, and analyzed the clinical characteristics. Results (1) There were 13 patients with conduction disturbances out of a total of 57 Behcet9s disease cases (22.8%) in our research: three patients with first-degree atrioventricular block; one patient with Mobtizs type I second- degree atrioventricular block; four patients with third-degree atrioventricular block; one patient with the left anterior branch block; one patient with complete right bundle branch block; three patients with first-degree atrioventricular block combined with the left anterior branch block or complete right bundle branch block. One patient (7.7%) died from infectious endocarditis and aortic root abscess during hospital stay. (2) Hemoglobin level was significantly lower in cases than controls (111.23±23.06 vs. 127.16±19.86 g/L, P=0.017); The median of albumin level in cases was higher than controls [34.5 (14.2) vs. 38.5 (9.9) g/L, P=0.032] (Table 1); C reactive protein level was higher in cases than controls [26.12 (21.3) vs. 6.7 (16.4) mg/L, P=0.045] (Table 1). (3) The aortic valvular insufficiency presented more frequently in patients in the case group than the control group (92.3% vs. 47.7%, respectively; P=0.004).Heart reconstruction can be seen in Behcet9patients with cardiac involvement. The echocardiography showed the following parameters were significantly different between two groups: left ventricular end-diastolic diameter (64.85±10.96 vs. 52.55±10.13 mm, P=0.001); left ventricular end-contraction diameter [48 (15) vs. 31 (13) mm, P=0.001]; left atrial diameter [50 (17) vs. 35.85 (13) mm, P=0.003]; outflow tract of right ventricle [26 (7) vs. 27 (6) mm, P=0.045] (4) Aortic valvular insufficiency was an independent risk factor for Behcet9s disease with conduction disturbances (OR =1.157, 95% CI 1.034, 1.293, P=0.011). Conclusions Behcet9s disease is one of the unusual etiologies of atrioventricular block. The evaluation of conduction disturbance should be kept in mind when diagnosing BD9s patient. References Desbois A C, Wechsler B, Cluzel P, et al.: Cardiovascular involvement in Behcet9s disease.Rev Med Interne 2014; 35(2):103–111. Braunwald E,Fauci A.S, Kasper D, et al.: Harrison9s principles of international medicine. New York: McGraw-Hill 2001,1287. Butt SU, McNeil J.: Complete heart block in a Caucasian woman with Behcet9s disease: a case report. J Med Case Rep 2016;19;10:102. Gao N, Han W, Ci WP,et al.: Clinical data analysis of cardiovascular involvement in Behcet9s disease. Zhonghua Yi Xue Za Zhi 2016,24;96(19):1523–6. Disclosure of Interest None declared