AB1021 Videocapillaroscopic findings in patients with systemic lupus erythematosus with or without jaccoud's arthropathy

Background Systemic lupus erythematosus (SLE) is an autoimmune disease that can present, as other collagen vascular disorders, changes in blood vessels. It can be evaluated by a non-invasive technique called periungual nailfold videocapillaroscopy (VCP). This technique is helpful in the diagnosis of systemic sclerosis (SSc), being part of the new classification criteria, and identifies individuals with Raynaud9s phenomenon who are at a higher risk for developing SSc. Objectives This study aims to describe the videocapillaroscopic profile of a series of SLE patients and investigate if the VCP pattern is different among those with Jaccoud9s arthropathy (JA) compared to the patients without this complication. Methods The patients were submitted to VCP, clinical evaluation, and laboratory tests. The capillaroscopic patterns were defined as minor, major and scleroderma (SD). The presence of capillaroscopic findings such as elongated capillaries, increased tortuosity, ectasia, prominent venous plexus, neoangiogenesis, hemorrhage and megacapillaries was also observed. Results In a population of 113 female patients with SLE (67 without JA and 46 with JA), at least one alteration was observed in VCP in 89.40% of patients, and the “nonspecific changes” were the most prevalent. Minor changes were seen in 39 (58.2%) and 26 (56.5%) patients, and major changes were seen in 21 (31.3%) and 11 (23.9%) patients without and with JA, respectively. The SD patterns were observed in 02 (3.0%) and 03 (6.5%) patients without and with JA, respectively (pu003e0.05). Conclusions The majority of patients of SLE present changes in the VCP exam, but such a tool does not allow distinguish those with or without JA. References Lambova SN, Muller-Ladner U. Capillaroscopic pattern in systemic lupus erythematosus and undifferentiated connective tissue disease: what we still have to learn? Rheumatology international. 2013;33(3):689–95. Ingegnoli F. Capillaroscopy abnormalities in relation to disease activity in juvenile systemic lupus erythematosus. Microvascular research. 2013;87:92–4. Santiago MB, Galvao V. Jaccoud arthropathy in systemic lupus erythematosus: analysis of clinical characteristics and review of the literature. Medicine. 2008;87(1):37–44. Ingegnoli F, Zeni S, Meani L, Soldi A, Lurati A, Fantini F. Evaluation of nailfold videocapillaroscopic abnormalities in patients with systemic lupus erythematosus. Journal of clinical rheumatology: practical reports on rheumatic u0026 musculoskeletal diseases. 2005;11(6):295–8. Ragab O, Ashmawy A, Abdo A, Mokbel A. Nailfold capilloroscopy in systemic lupus erythematosus. The Egyptian Rheumatologist. 2011;33:61–7. Acknowledgements M. B.S. has received a scholar ship from Conselho Nacional de Desenvolvimento Cientifico e Tecnolόgico (CNPq). Disclosure of Interest None declared