Dibrominated camphoric acid derived salen complexes: Synthesis, characterization and cytotoxic activity
Polyhedron(2017)
摘要
The Cu(II) complex of the dibrominated ligand (1R,3S)-N,N′-bis[5-bromosalicylidene]-1,3-diamino-1,2,2-trimethylcyclopentane was synthesized and screened for in vitro cytotoxic activity against HCC1806 and MCF7 breast cancer and LS1034 and WiDr colon cancer cells lines. IC50 values of 0.95–2.32μM were observed, constituting a marked improvement relative to current conventional chemotherapy.
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关键词
Metal complexes,Halogenated salen ligands,Cytotoxic activity,Theoretical calculations,Electrochemical studies
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