Dibrominated camphoric acid derived salen complexes: Synthesis, characterization and cytotoxic activity

M. Elisa Silva Serra,Dina Murtinho,Zênis N. da Rocha,Ana Salomé Pires, João Gabriel Baptista,Ana Margarida Abrantes,Mafalda Laranjo,João Eduardo Casalta-Lopes,Maria Filomena Botelho,Alberto A.C.C. Pais,Sandra C.C. Nunes,Hugh D. Burrows,Telma Costa

Polyhedron（2017）

引用 13|浏览19

暂无评分

摘要

The Cu(II) complex of the dibrominated ligand (1R,3S)-N,N′-bis[5-bromosalicylidene]-1,3-diamino-1,2,2-trimethylcyclopentane was synthesized and screened for in vitro cytotoxic activity against HCC1806 and MCF7 breast cancer and LS1034 and WiDr colon cancer cells lines. IC50 values of 0.95–2.32μM were observed, constituting a marked improvement relative to current conventional chemotherapy.

查看译文

关键词

Metal complexes,Halogenated salen ligands,Cytotoxic activity,Theoretical calculations,Electrochemical studies

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要