Lymphatic drainage system of the brain: A novel target for intervention of neurological diseases

•The brain lymphatic drainage system may include perivascular pathway, glymphatic system, olfactory/nasal and meningeal lymphatics.•The brain lymphatic drainage system maintains homeostasis of brain and participates in immune responses and surveillance.•The integrate function of the brain lymphatic system is dependent on selectivity and complementarity of each component.•Effectiveness of the brain lymphatic drainage system is regulated under physiological and neuropathological conditions.•The brain lymphatic drainage system represents a novel therapeutic target to treat neurological dysfunctions.