A 3-month safety and efficacy study of travoprost 0.004% ophthalmic solution compared with timolol in pediatric patients with glaucoma or ocular hypertension
Journal of American Association for Pediatric Ophthalmology and Strabismus(2017)
Abstract
Purpose To evaluate efficacy and safety of travoprost in pediatric patients with ocular hypertension or glaucoma and demonstrate its noninferiority to timolol. Methods Patients aged 2 months to Results Of 157 patients included (mean age, 9.6 years), 77 received travoprost and 75 timolol. All patients experienced a significant reduction in IOP in the study eye at 3 months: the mean IOP change from baseline was −5.4 mm Hg for travoprost; −5.3 mm Hg, for timolol. The mean difference between travoprost and timolol at month 3 was −0.1 mm Hg (95% CI, −1.5 to 1.4 mm Hg). The most common treatment-related adverse events for the travoprost group were ocular hyperemia and eyelash growth. No serious adverse events were reported. Conclusions This study found travoprost to be noninferior to timolol in lowering IOP in patients with pediatric glaucoma or ocular hypertension. Travoprost was well-tolerated, and no treatment-related systemic adverse events were reported.
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Key words
ocular hypertension,glaucoma,ophthalmic solution,travoprost,timolol
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