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Arginine Deprivation Sustains Pd1 Expression Via Gcn2 To Promote Immune Escape In Multiple Myeloma: A Novel Metabolic And Immune Check-Point

Alessandra Romano,Nunziatina Laura Parrinello,Ugo Orfanelli,Michela Ghizzinardi,Laura Oliva,Matteo Trudu,Piera La Cava,Francesco Di Raimondo,Simone Cenci,Francesca Paradiso, Irene Ingordo,Floriana Cremasco

CLINICAL LYMPHOMA MYELOMA & LEUKEMIA（2017）

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Abstract
Despite PD-1 inhibitors pembrolizumab and nivolumab are promising agents in hematological malignancies, obejective response in multiple myeloma (MM) is dismal due to the immune-suppressive bone marrow (BM) environment. Our previous work showed that arginine deprivation, due to increased arginase-1 (Arg-1)-positive myeloid-derived-suppressor cells (MDSC), sustains MM progression, but its role in modulating PD1 axis is unknown.
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Key words
multiple myeloma,promote immune escape,gcn2,check-point
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