Kupffer cells activation promoted binge drinking-induced fatty liver by activating lipolysis in white adipose tissues
Toxicology(2017)
Abstract
•GdCl3 and etanercept attenuated binge drinking-induced hepatic TG accumulation by a similar amount.•GdCl3 and etanercept had no effects on ethanol-induced disturbance of PPAR-α and SREBP-1c.•GdCl3 and etanercept suppressed binge drinking-induced phosphorylation of HSL.•TNF-α promoted HSL phosphorylation and lipolysis in cultured epididymal adipose tissues.
MoreTranslated text
Key words
ACC,ACOX,AFL,ALD,ALT,AST,AMPK,CPT-1,CYP2E1,FAS,FFA,HSL,KCs,LFABP,LPS,MDA,NO,PPAR-α,ROS,SREBP-1c,TG,TNF-α
AI Read Science
Must-Reading Tree
Example
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
Generate MRT to find the research sequence of this paper
Chat Paper
Summary is being generated by the instructions you defined