Assessment of DNA methylation patterns in breast tumours and apparently healthy subjects in Anambra state, Nigeria

90% of total breast cancer cases [3].The majority of breast cancers are sporadic caused by more complicated reasons such as the activation of mitogenic signaling pathways and loss of tumor suppressor expression epigenetically etc., [4].DNA methylation which is one of the epigenetic mechanisms, which involves the addition of a methyl group to unmodified DNA, is described as an epigenetic change resulting from environmental influence, because it is a chemical modification to DNA not a change brought about by a DNA mutation [5].Normal methylation of DNA would mark the DNA and enable such actions as turning genes on or off.Thus if epigenomic alteration persists in a tumour suppressor