Evaluation of Adverse Events Following Immunization against Rotavirus Regardless of Recommended Age Restriction

Introduction: Mildand moderate Adverse Events Following Immunization (AEFI) against Rotavirus hasnot received much attention when the vaccine is administered regardless ofrecommended age restriction. Objectives: To describe the behavior ofmild and moderate AEFI in immunized subjects against Rotavirus, in who agerestriction period had not been considered. Methods: A case-controlstudy in which we included immunized patients with monovalent oral vaccineagainst rotavirus and divided them into two groups: 1) Infants who received RV1vaccine without considering the recommended period, and 2) Infants who werevaccinated with the recommended schedule. Results: From the total doses,143/1894 (7.5%) were administered outside the restriction period. The mostfrequent AEFIs with the first dose were purpura, polypnea, and rhinorrhea; For the second dose: purpura,bloody stools, irritability and rhinorrhea. Conclusions: This studyshows the benefits from vaccination regardless of age restriction are morebeneficial compared to the possible risks of AEFI.