SAT0533 Association of osteoarthritis and periodontitis based on the korea national health and nutrition examination survey

Background Osteoarthritis (OA) is a chronic joint disease with complex etiologies characterized by synovial inflammation, subchondral bone remodeling, and the formation of osteophytes, which leads to cartilage deterioration. Periodontitis (PD) is also a chronic inflammatory disease characterized by loss of periodontal ligament and alveolar bone. Recently, the association between OA and metabolic diseases has been proposed, and the association between several systemic diseases such as rheumatoid arthritis, metabolic syndrome and periodontitis has been also revealed. Objectives The aim of this study was to investigate the association between OA and PD in South Korea using data from the Korea National Health and Nutrition Examination Survey (KNHANES) during 2010–2014. Methods Cross-sectional data of 7,969 adults who completed the KHANES, and participated in both a periodontal examination and a knee imaging were analyzed. OA of knee was defined when a participant had knee arthralgia and showed radiographic change of Kellgren-Lawrence (KL) grade over 1. OA patients were grouped into mild (KL grade 1–2) and severe (KL grade 3–4) OA. The periodontal status was assessed by the Community Periodontal Index. Binary logistic regression analysis was performed according to the OA and PD status, severity of OA, and subgroups (age, gender) adjusting for the socio-demographics, oral health behaviors and status, smoking, and drinking. Results Of the 7,969 participants, 1408 (17.7%) had OA and 2987 (37.5%) had PD. OA and PD showed no significant association in overall analysis. However, in subgroup analysis, female patients with severe OA were more likely to have PD (adjusted odd ratio (OR) 1.377, P=0.0316); likewise, OR for severe OA in female patient with PD was 1.367. (P=0.0.54) Conclusions Severe OA and PD were associated with each other especially in female in the Korean population. Further prospective and experimental studies are necessary to identify the impact and mechanisms of association between severe OA and PD in female. References Zhuo Q, Yang W, Chen J, Wang Y. Metabolic syndrome meets osteoarthritis. Nature reviews Rheumatology 2012; 8(12): 729–37. Kwon YE, Ha JE, Paik DI, Jin BH, Bae KH. The relationship between periodontitis and metabolic syndrome among a Korean nationally representative sample of adults. Journal of clinical periodontology 2011; 38(9): 781–6. Disclosure of Interest None declared