Tie2-Mediated Epigenetic Marks Regulate Therapeutic Resistance Of Glioblastoma

Glioblastomas (GBs), the most common subtype of primary brain tumors in adults, are resistant to current strategies of surgery, irradiation and chemotherapy with a median survival that ranges from 9 to 15 months. GBs invariably recur after therapy due to the presence of cells exhibiting a multidrug-resistance phenotype in the core of the tumor. There is an urgent need of developing the new therapeutic strategies for brain tumor treatment including the identification of novel molecular pathways regulating this resistant phenotype. One of the key phenomena of GB is that tyrosine kinase receptors (TKRs) are abnormally regulated and related to poor treatment outcomes. We have previously reported the expression of TIE2 in human surgical glioma specimens in relation to malignancy, and the role of TIE2 in endothelial-glioma adhesion, tumor invasion and multi-drug resistance of gliomas. Recently, we have identified …