[PP.15.27] USE OF 99 M TC-HMPAO BRAIN SPECT ON PATIENTS WITH RESISTANT HYPERTENSION TO ASSESS THE SAFETY OF RENAL DENERVATION

Objective: To determine the speed change of cerebral blood flow after radiofrequency ablation of the renal arteries in patients with arterial hypertension resistant to drug therapyDesign and method: The study included 13 patients (average age 54,2 ± 11.4 years) with arterial hypertension resistant to drug therapy. All patients underwent office blood pressure measurement, brain SPECT with 99m Tc-HMPAO at baseline and after 6 months after renal denervation Results: According to office measurements, baseline blood pressure amounted to 166,9/101,1 mmHg with the decline -24,6/-14,8 mmHg 6 months after denervation (p < 0.05). When comparing indices of regional cerebral blood flow obtained when brain SPECT showed no signs of deterioration of cerebral perfusion and reduce the speed of cerebral circulation. On the contrary, in some regions of the brain marked by a significant increase in the speed of cerebral blood flow: in the right rear parietal, occipital right and left frontal and right-lower areas (p < 0.05). These results allow us to speak not only about security but also the positive impact of renal denervation on cerebral blood flow, probably due to the persistent decline in systemic arterial pressure. No patient included in the study were recorded adverse side effects related to the denervation. Dynamics of the level of blood creatinine or signs of stenosis of the renal arteries after ablation have not been identified Conclusions: In patients with resistant hypertension conducting renal denervation contributes to a significant reduction of office blood pressure. When evaluating the effect of renal denervation on the brain as one of the main target organs of hypertension, revealed no reduction in the level of cerebral blood flow and cerebral perfusion, suggesting the safety of this procedure.