An Intramolecular Cycloaddition Approach to Construct Polysubstituted Pyrrolidones from Alkynyl Carboxamides and PTSA
SYNTHESIS-STUTTGART(2017)
Abstract
An efficient synthetic route to highly substituted pyrrolidone derivatives has been developed from an easily available alkynyl carboxamide and 4-methylbenzenesulfonic acid (PTSA). In the reaction, PTSA is not only used as acid catalyst but also as a reactant to provide a source for OTs group. A mechanism is proposed to involve the protonation of the alcohol substrate/cyclopropylcarbinol-homoallylic rearrangement/intramolecular N-nucleophilic cyclization reactions.
MoreTranslated text
Key words
pyrrolidones,alkynyl carboxamides,PTSA,intramolecular cyclization,ring opening
AI Read Science
Must-Reading Tree
Example
Generate MRT to find the research sequence of this paper
Chat Paper
Summary is being generated by the instructions you defined