Comparison of various coupling reagents in solid-phase aza-peptide synthesis
Tetrahedron Letters(2017)
摘要
•Reaction rates and yields of aza-peptide formation depends on the activator structure.•Peptide bond forms 30 times faster than the aza-peptide bond.•Activators COMU and PyOxim lead to nearly complete aza-peptide bond formation.
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关键词
Activators,Aza-peptide,Kinetics,SPPS
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