Methotrexate, combined with cyclophosphamide attenuates murine collagen induced arthritis by modulating the expression level of Breg and DCs
Molecular Immunology（2017）
Abstract
•The combination of MTX and CTX had a more pronounced effect in CIA mice.•CTX and MTX treated mice showed a lower frequency of B cells in CIA mice bone marrow.•CTX combined with MTX were more effective in suppressing inflammatory response in CIA mice.•CTX combined with MTX were more effective in suppressing several immune cells in CIA mice.
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Key words
Collagen-induced arthritis,Methotrexate,Cyclophosphamide,Regulatory B cells,Dendritic cells
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