Association Of Body Mass Index (Bmi) And Stage In Patients With Non-Small Cell Lung Cancer Harboring Kras Mutations.

e13071Background: Body mass index (BMI) is inversely associated with lung cancer risk, particularly in former or current smokers. KRAS mutant non-small cell lung cancer (NSCLC) has been shown to be highly associated with smoking status. Therefore, we sought to investigate the association of BMI and stage in a cohort of patients with KRAS mutant NSCLC. Methods: Patients with KRAS mutant lung cancer who underwent tumor genotyping using next generation sequencing testing were identified. BMI( kg/m2 ) was categorized as: Underweight ( u003c 18.5), normal weight (18.5 – 24.9), overweight (25-29.9) and obese (≥30). Chi-square and t-tests were performed to test association between stage (I vs. II+) and BMI (4 categories), and stage and BMI as a continuous variable, respectively. Results: From 5/2013 to 9/2016, 201 patients with KRAS mutant NSLC were identified. Of these, 178 (88.6%) were current or former/ever smokers (SM) and 23 (11.4%) were never smokers (NS). In the SM group, 114 were female and 64 male with a me...