Deregulated Genes in Hematopoietic Stem Cells Isolated from Spleen of Patients with Myelofibrosis

An important issue in myeloproliferative diseases research is to test the hypothesis that in the neo-angiogenesis, which is observed in the spleen and bone marrow of patients, involves endothelial cells derived from the neoplastic clone. In this study we analyzed the gene expression profile of 138 genes in CD34+ hematopoietic cells from the spleen and peripheral blood of patients with myelofibrosis (MF) and healthy individuals (HI). These genes have been selected among those that characterize the neoangiogenic gene signature or belonging to deregulated expression pathways in MF, and are listed in Table1.