Expression of MGMT, hMLH1 and XRCC1 in Gastric Cancer Tissue and Their Clinical Significance

Objective: To study the expression and their correlation of repair gene MGMT, hMLH1 and XRCC1 and to explore the relationship between their expressions and clinicopathologic features of gastric cancer. Methods: Immunohistochemical SP method was used to detect the expression of repair gene MGMT, hMLH1 and XRCC1 in 52 gastric cancer specimens. The relationship between MGMT, hMLH1, XRCC1 and clinicopathological features and the correlation between MGMT and hMLH1 and XRCC1 were analyzed. Results: The positive rates of MGMT, hMLH1 and XRCC1 proteins were 75.0% (39/52), 63.7% (33/52) and 76.8% (40/52), respectively. The expression MGMT protein was positively correlated to the expression of hM-LH1 (r = 0.498, P < 0.05), but no obvious correlation to the expression of XRCC1 (P > 0.05). The MGMT expression was associated with histological pattern, lymphatic metastasis, distant metastasis and postoperative recurrence (P < 0.05, or P < 0.01) but not associated with gender, age, invasive depth and tumor staging (P > 0.05). hMLH1 expression was related to histological pattern, lymphatic metastasis and postoperative recurrence (P < 0.05, or P < 0.01), but not related to gender, age, tumor staging, invasive depth and distant metastasis (P > 0.05). XRCC1 expression was related to histological pattern, lymphatic metastasis, tumor staging and postoperative recurrence (P < 0.05, or P < 0.01), but not related to gender, age, invasive depth and distant metastasis (P > 0.05). Conclusion: MGMT, hMLH1 and XRCC1 expression is closely related to the occurrence of gastric cancer and has the effect against the development of gastric cancer.