Ixodicidal compounds from pre-domesticated Lavandula luisieri

•Pre-domesticated Lavandula luisieri.•Larvicidal effects of plant extracts against the hard tick Hyalomma lusitanicum.•Bioguided fractionation of the hydrolate organic fraction.•The activity of the extracts and fractions correlated with larvicidal necrodanes.•Necrodanes can be a new class of ixodicidal agents.