Impact Of Cd8 Stromal Lymphocytes In Bc Patients With The Addition Of Autologous Dendritic Cell Vaccination To Neoadjuvant Chemotherapy.

1081Background: Levels of tumor infiltrating lymphocytes (TILs) at diagnosis have shown to improve survival in TNBC and HER2 overexpressing breast cancer (BC) patients. Indeed, high levels of TILs after neoadjuvant chemotherapy (NAC) in the residual tumor have been related to a better outcome in BC patients. Thus, we have quantified stromal CD8 TILs pre- and postNAC in our cohort of patients treated with NAC plus dendritic cell vaccines (cohort V) (NCT01431196) and in an historic cohort of patients treated with the same NAC without the vaccine (cohort C) in order to check if the addition of immunotherapy helps to increase TILs in the residual BC. Our previous data have showed an improved pCR and the stimulation of lymphocyte populations in the blood in cohort V. Methods: Classification of molecular subtypes was performed based on IHC. We evaluated percentage of TILs by two different pathologists using stained CD8 core biopsy sections taken at diagnosis and after NAC therapy in a prospectively defined retr...