Obesity And Survival In The Neoadjuvant Breast Cancer Setting: Role Of Tumor Subtype And Race.

e12136Background: Obesity may adversely influence survival in breast cancer; however, studies are conflicting and limited in the neoadjuvant setting. Results may also vary by tumor subtype and race/ethnicity. Our study seeks to examine associations between obesity and survival in women receiving neoadjuvant chemotherapy (NAC) and the role of tumor subtype and race/ethnicity. Methods: In a retrospective review of women with operable invasive breast cancer administered Adriamycin/Taxane-based NAC at a single intuition from 2004-2016, we identified n = 273 women with completed BMI data at diagnosis. Obesity was defined as body mass index (BMI) u003e = 30. We assessed associations between obesity and progression-free survival (PFS), using STEEP criteria, and overall survival (OS), using all-cause mortality, both overall and stratified by tumor subtype in three groups: Hormone Receptor Positive (HR+)/HER2- (n = 135), HER2+ regardless of hormonal status (n = 94), and Triple Negative Breast Cancer (TNBC) (n = 44), e...