380 Comparisons of fatigue, anxiety and depression in systemic lupus erythematosus, systemic sclerosis and anti-neutrophil cytoplasmatic antibody-associated vasculitis

Background and aims To compare fatigue, anxiety and depression between systemic lupus erythematosus (SLE), systemic sclerosis (SSc) and anti-neutrophil cytoplasmatic antibody associated vasculitis (AAV). Methods Patients filled in self-assessments of fatigue (Multi Assessment of Fatigue Scale, MAF) and anxiety/depression (Hospital Anxiety and Depression Scale). Sub-analyses of MAF were conducted of global fatigue (scale 1–50) and subscales regarding degree, severity, distress and impact on daily activities (scale 1–10 for each). Results are presented as median (inter-quartile range). Results We included 857 patients (77% women), age 18–85 years, disease duration 0–58 years. Persons with SLE were younger 47(34-57) than persons with SSc 60(52-69) p SLE patients reported a higher anxiety level and more impact of fatigue on all analysed subscales compared to the AAV patients, and all but impact on daily activities compared to SSc. SSc and AAV had a similar pattern on all analysed components (Table 1). Among persons with disease duration less than a year, SLE still scored highest on all components of fatigue, but interestingly AAV patients reported similar figures to SLE regarding the severity and distress of fatigue (Table 2). Conclusions Fatigue and anxiety was assessed to be more pronounced and have more impact on daily actives in SLE patients compared to SSc and AAV patients. However in persons with short disease duration the pattern of fatigue in SLE was more similar to AAV than SSs.