Effect Of Estrogen Therapy On Ovarian Tumor Cells Treated With Cisplatin

Objective: Previous clinical trials indicate that estrogen replacement therapy after debulking surgery does not have a negative effect on progression-free or overall survival. The aim of this study was to determine the in vitro effects of estrogen on ovarian cancer cells during and after treatment with chemotherapy. We hypothesize that estrogen therapy after ovarian cancer debulking is not harmful and, in platinum-resistant disease, may actually increase tumor sensitivity to chemotherapy.