Removal of soluble Fms-like tyrosine kinase (sFlt-1) by plasma-specific apheresis: pilot study in women with very preterm preeclampsia

W Schaarschmidt,H Hagmann,B Roth, T Cingoez,A Karumanchi,J Wenger, Kj Lucchesi,H Tamez,T Lindner, A Fridmann,U Thome,A Kribs,M Danner, S Hamacher,P Mallmann,Holger Stepan,T Benzing,R Thadhani

Zeitschrift Fur Geburtshilfe Und Neonatologie（2015）

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摘要

Background: Soluble Fms-like tyrosine kinase-1 (sFlt-1) is a potential therapeutic target in preeclampsia. We evaluated the safety and efficacy of treating women with very preterm preeclampsia using a plasma-specific dextran sulfate (PSDS) column to remove circulating sFlt-1.

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Preeclampsia

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