The rs8135828 polymorphism of the THO complex subunit 5 (THOC-5) gene and its correlation to lipid and metabolic profile in mid-aged women

Rita Loja-Chango,Danny Salazar-Pousada,Gustavo S. Escobar-Valdivieso,Cecibel Ramírez-Morán, Jasson Espinoza-Caicedo,Faustino R. Pérez-López,Peter Chedraui

Maturitas（2017）

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摘要

Background: THO (suppressors of the transcriptional defects of hpr1delta by overexpression) complex, sub-unit 5 (THOC-5), is part of the mRNA TREX complex (TRanscription-EXport); important for transcription, mRNA packaging and nuclear exportation. Reports have correlated specific polymorphic variations of the gene coding for this complex with abnormal HDL-C metabolism.

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lipid,metabolic profile,rs8135828 polymorphism,gene,mid-aged

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