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Identification and synthesis of novel inhibitors of mycobacterium ATP synthase

Yogesh B. Surase,Kirandeep Samby, Sagar R. Amale,Ruchi Sood,Kedar P. Purnapatre,Pawan K. Pareek,Biswajit Das, Kamna Nanda, Subodh Kumar,Ashwani K. Verma

Bioorganic & Medicinal Chemistry Letters（2017）

Cited 20|Views5
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Abstract
Novel series of non-DARQ (DiARyl Quinoline) template as ATP synthase inhibitor have been identified and scaffold hopping approach led to compound 14b, with potent ATP synthase activity and MIC against MTb.H37Rv.
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Key words
ATP synthase,Non-darq,TMC207,Anti-tubercular,Mtb
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