MicroRNAs that affect the Fanconi Anemia/BRCA pathway are downregulated in imatinib-resistant chronic myeloid leukemia patients without detectable BCR-ABL kinase domain mutations

•IM-resistant CML patients without BCR ABL mutations have a distinct miRNA profile.•MiR-146a-5p, miR-99b-5p and miR-151a-5p are the top most downregulated miRNAs.•These miRNAs regulate genes that are involved in the Fanconi Anemia (FA) pathway.•The FA pathway provides BCR ABL-independent mechanisms of IM resistance.