Acute Changes In Endothelial Function With Cisplatin Among Germ Cell Tumor (Gct) Patients (Pts).

9587 Background: We hypothesized that the increased risk of cardiovascular disease (CVD) in GCT pts following cisplatin-based chemotherapy (CBCT) may be due to endothelial damage. Methods: In this pilot study, men age ≥18 with GCT, no prior chemotherapy (CT) or radiation, and no history of CVD were enrolled to the CT group (CG) if CBCT was planned and to the surgery group (SG) if only surgical management (orchiectomy +/- RPLND) was planned. Endo-PAT2000, a noninvasive method of quantifying endothelial function, was used to measure the peripheral arterial tonometry reactive hyperemia index (PAT-RHI). Lower values correlate with endothelial dysfunction. Circulating endothelial cells (CECs) were quantified by immunomagnetic capture as a secondary endpoint. Covariates included hypertension, smoking status, dyslipidemia, diabetes, and fasting lipids, glucose, HbA1C, and testosterone. Measurements were obtained at time points T1-T5 for CG pts and T1, T2 and T5 for SG pts (Table). Nonparametric tests were used t...