Oncostatin M regulates CYP7A1, the rate-limiting enzyme in bile acid biosynthesis, and contributes to the pathogenesis of non-alcoholic fatty liver disease
Zeitschrift Fur Gastroenterologie(2017)
摘要
Oncostatin M (OSM) is an IL-6 family cytokine released by activated monocytes/macrophages, neutrophils and dendritic cells in the early phase of inflammatory processes. Recent studies using Osmr-/- mice determined a protective function of OSM in metabolic disorders. Increasing evidence suggests that hypercholesterolemia is a crucial factor in non-alcoholic fatty liver disease (NAFLD) pathogenesis. As Ldlr-/- mice are a physiological model of NAFLD and hypercholesterolemia we investigated the influence of OSM on NAFLD in genetic mouse models on C57/Bl6 and Ldlr-/- background.
更多查看译文
关键词
bile acid biosynthesis,liver,enzyme,pathogenesis,rate-limiting,non-alcoholic
AI 理解论文
溯源树
样例
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要