Improved synthesis of unnatural amino acids for peptide stapling
Tetrahedron Letters(2017)
Abstract
•Efficient synthesis of the unnatural amino acids for stapled peptide was developed.•Synthesis strategy by chiral Ni(II) complex was modified and optimized.•α-Bisalkenyl amino acid was synthesized by achiral Ni(II) complex strategy.•Reaction condition, yield, atom economy, and optical purity were optimized.
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Key words
Stapled peptide,Unnatural amino acids,Asymmetric synthesis,Ni(II)-complex
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