PRECONDITIONED MSC AND EARLY MICROVASCULAR DISTURBANCES IN A MOUSE SEPSIS MODEL

Sepsis is a complex disease characterized by an inflammatory host response to infectious stimulus. Patients often die within a context of multiple organ dysfunction syndrome (MODS), while the macro-hemodynamic parameters have been corrected and that early antibiotic therapy was administered. For several years, many studies have shown that microcirculation plays a key role in the development of MODS. Microcirculation injury affects vascular autoregulatory mechanisms, capillary permeability and leukocyte-endothelium interactions. Even if leukocytes activation and recruitment are essential to an effective host defense against infection, these interactions have been implicated in inflammation mediated vascular injury, which leads to end-organ injury.