Investigation of the effect of medium in the preparation of alendronate: till now the best synthesis in the presence of an ionic liquid additive
HETEROATOM CHEMISTRY(2017)
摘要
The synthesis of the drug alendronate from -aminobutyric acid and phosphorus trichloride/phosphorous acid as the P-reagents is revisited using methanesulfonic acid and sulfolane as solvents and ionic liquids (ILs) as additives according to a novel approach. Besides elaborating efficient synthetic methods with a record yield of up to 80%, the misleading literature data were also clarified. It is a novel trend to use ILs as only catalysts or additives and not as solvents.
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关键词
alendronate,synthesis,-aminobutyric acid,P(III)-reagents,sulfolane,ionic liquids
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