Antidiabetic sFRP5 is downregulated in patients with chronic periodontitis

Diabetes mellitus in humans is known to be associated with periodontitis. Periodontitis is an inflammatory disease affecting 11.2% of the global population and even > 30% germans. Yet, mechanistical links between these two diseases are not fully understood. Here, we investigate the role of diabetes markers and the antidiabetic adipokine secreted frizzled-related protein5 (sFRP5) in chronic progressive periodontitis with tooth loss (PP).