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Facile synthesis of fluoro, methoxy, and methyl substituted ferrocene-based urea complexes as potential therapeutic agents

Faiza Asghar,Amin Badshah,Bhajan Lal,Shumaila Zubair,Saira Fatima,Ian S. Butler

Bioorganic Chemistry（2017）

Cited 16|Views3
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Abstract
The DNA binding proficiency of ferrocenyl ureas (F1–F9) investigated by CV, UV and viscometry establish them as decent DNA binders with electrostatic mode of interaction. The compounds also revealed good antioxidant activities. DFT based HOMO and LUMO energies correlate well with experimentally determined redox potential values.
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Key words
Ferrocene-based ureas,DNA interaction,Free radical scavenging,DFT measurements,Cytotoxicity
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