111. White Matter Microstructural Variations in Adolescents with Affective Symptoms

Adolescence is a period of transition related to structural brain circuit remodelling involving myelination as one of the main mechanisms. The adolescent affective phenomenology might include major depression episodes or subthreshold pictures. It is unknown how these conditions will interplay with the trajectories of brain myelination in adolescents. We searched to identify the changes in white matter microstructure associated with affective symptoms in adolescents, and their relation to follow-up outcomes.