Mechanism Of Action Of Novel Modulators Of Serotonin, Dopamine, And Mu Opiate Receptors For Treatment Of Mood Disorders

A series of novel compounds has been discovered that bind 5-HT2A, D1 and mu opiate receptors. This series is exemplified by ITI-333, which possesses low nanomolar affinity for 5-HT2A, D1 and mu opiate receptors with Ki values of 8.3nM, 50nM and 11nM, respectively. Here, we report the pharmacological profile of ITI-333.