Different Effects Of Nr2b Antagonists On Behavior Paradigms In Mice

NR2B subunit-specific negative allosteric modulators (NAM) have raised interest for their potential to treat patients suffering from depression with efficacy similar to the unselective NMDA-R antagonist ketamine but with improved tolerability. Two different NR2B NAMs were explored in clinic: traxoprodil and Cerc-301. In this study we investigated both compounds for efficacy and tolerability in rodents.