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Novel non-trimethoxylphenyl piperlongumine derivatives selectively kill cancer cells

Youjun Zhang,Hao Ma,Yuelin Wu,Zhongli Wu,Zhengguang Yao,Wannian Zhang,Chunlin Zhuang,Zhenyuan Miao

Bioorganic & Medicinal Chemistry Letters（2017）

Cited 15|Views23
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Abstract
Twelve analogues have been designed and synthesized with non-substituted benzyl rings or heterocycles in this work.
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Key words
Piperlongumine,Natural product,Drug design,Structure-activity relationships,Anticancer
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