Role of miR-15a/miR-16-1 and the TP53 axis in regulating telomerase expression in chronic lymphocytic leukemia

HAEMATOLOGICA(2017)

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摘要
Chronic lymphocytic leukemia (CLL), the most prevalent form of leukemia in adults in the western world, has a highly heterogeneous clinical course, and is characterized by genomic instability which gives rise to several chromosomal alterations detectable in more than 80% of CLL cases.[1][1] While
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