Quantitative detection of an IDH2 mutation for minimal residualdisease monitoring in acute myeloid leukemia patients and itscomparison with mutations in the NPM1 gene
Leukemia & Lymphoma(2013)
摘要
Acquired mutations in the IDH1 and IDH2 genes have been
detected in various hematological disorders, including acute
myeloid leukemia (AML), where the incidence has been reported
to be 15%. The IDH1 and IDH2 genes encode enzymes that catalyze
oxidative decarboxylation of isocitrate to alpha-ketoglutarate
(alpha-KG). Somatic mutations cause their dysfunction and an
accumulation of aberrant 2-hydroxygluterate (2-HG) product in
cells. The decreased supply of alpha-KG or increased
accumulation of 2-HG (i.e. metabolic biomarker of mutant IDH1/2
enzyme activity) is considered to be a possible basis for the
oncogenic properties of IDH mutants.
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关键词
idh2 mutation,acute myeloid leukemia patients,minimal residualdisease monitoring,mutations
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