MP72-02 FAVORABLE PROGNOSIS OF PATIENTS WITH END-STAGE RENAL DISEASE PATIENTS AND RENAL CELL CARCINOMA: A LONG-TERM FOLLOW-UP STUDY AT A SINGLE INSTITUTION

You have accessJournal of UrologyKidney Cancer: Localized: Surgical Therapy V1 Apr 2017MP72-02 FAVORABLE PROGNOSIS OF PATIENTS WITH END-STAGE RENAL DISEASE PATIENTS AND RENAL CELL CARCINOMA: A LONG-TERM FOLLOW-UP STUDY AT A SINGLE INSTITUTION Shunichi Namiki, Yoshihiro Ikeda, Takashi Kudo, Masataka Aizawa, and Naaomasa Ioritani Shunichi NamikiShunichi Namiki More articles by this author , Yoshihiro IkedaYoshihiro Ikeda More articles by this author , Takashi KudoTakashi Kudo More articles by this author , Masataka AizawaMasataka Aizawa More articles by this author , and Naaomasa IoritaniNaaomasa Ioritani More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2017.02.2238AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES We aimed to define the clinical features of renal cell carcinoma (RCC) arising in patients with end-stage renal disease (ESRD). METHODS A total of 261 patients (male, n=221; female, n=40; median age, 56 years; range 21 - 81 years) with ESRD and RCC who underwent radical nephrectomy at our institute between November 1985 and June 2016. The dialysis status of all patients at the time of diagnosis was chronic renal failure. Information was collected about age, sex, symptoms, duration of dialysis therapy, tumor staging and grading, histological subtype and outcome, and the median post-surgical follow up was 78 (range 1 - 368) months. RESULTS The median duration of dialysis before surgery was 146 (range 1 - 400) months. Symptomatic RCC was evident in 24 (9.1%) patients, and gross hematuria was the most frequent complaint (12 patients). Renal cell carcinoma was incidentally diagnosed in 237 (90.9%) patients by ultrasonography or computed tomography screening. Bilateral RCC was observed in 56 patients (21%). Thus, radical nephrectomy was performed in 317 kidneys. Mean maximum tumor size was 2.45 cm. Organ-confined cancer was pathologically proven after radical nephrectomy in 98% of the patients, including 86% of those with pT1 (tumors < 7cm). Only four patients had advanced RCC (pT3). The histological subtypes were clear cell, papillary in 76 (24%) and dialysis-related renal tumors in 233 (74%), 76 (24%) and 8 (3%) patients, respectively. Three patients died of renal cancer and 31 died due to other causes. The estimated 5- and 10-year overall survival rates were 95% and 89%, respectively. Especially, the estimated 5- and 10-year cancer-specific survival rates were both 98.8%. CONCLUSIONS Long-term outcomes for patients with RCC and ESRD were favorable in this study. Therefore, the early detection of tumors is particularly important for the optimal survival of patients with RCC and ESRD. This can be achieved through regular monitoring by abdominal ultrasonography or computed tomography. © 2017FiguresReferencesRelatedDetails Volume 197Issue 4SApril 2017Page: e954 Advertisement Copyright & Permissions© 2017MetricsAuthor Information Shunichi Namiki More articles by this author Yoshihiro Ikeda More articles by this author Takashi Kudo More articles by this author Masataka Aizawa More articles by this author Naaomasa Ioritani More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...