MP58-16 ONCOLOGIC OUTCOMES OF SQUAMOUS CELL CARCINOMA VERSUS UROTHELIAL CARCINOMA WITH SQUAMOUS DIFFERENTIATION AFTER RADICAL CYSTECTOMY FOR MUSCLE INVASIVE BLADDER CANCER (MIBC)

You have accessJournal of UrologyBladder Cancer: Invasive V1 Apr 2017MP58-16 ONCOLOGIC OUTCOMES OF SQUAMOUS CELL CARCINOMA VERSUS UROTHELIAL CARCINOMA WITH SQUAMOUS DIFFERENTIATION AFTER RADICAL CYSTECTOMY FOR MUSCLE INVASIVE BLADDER CANCER (MIBC) Mahmoud Laymon, Ahmed Mansour, Mohamed M. Elsaadany, Ahmed Mosbah, Shaaban AA, and Hassan Abol-enein Mahmoud LaymonMahmoud Laymon More articles by this author , Ahmed MansourAhmed Mansour More articles by this author , Mohamed M. ElsaadanyMohamed M. Elsaadany More articles by this author , Ahmed MosbahAhmed Mosbah More articles by this author , Shaaban AAShaaban AA More articles by this author , and Hassan Abol-eneinHassan Abol-enein More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2017.02.1811AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES To compare clinicopathological characteristics and oncologic outcomes between patients treated with radical cystectomy for pure squamous cell carcinoma (SCC) and urothelial carcinoma with squamous differentiation (SqD). We also, aimed to identify predictors of cancer specific survival (CSS) for each histologic variant. METHODS We reviewed data of 1737 consecutive patients treated with radical cystectomy between January 2004 till February 2014. A total of 318 and 223 patients were diagnosed with SCC and SqD respectively. Squamous differentiation was defined as intercellular bridges or keratinization in the tumor. Kaplan-Meier survival curves were used to estimate CSS. RESULTS Patients' demographics are illustrated in Table1. Patients with SqD were significantly more likely to have extravesical (58.3% vs 46.2%.p = 0.006) and nodal positive disease (34.5% vs 14.5%. p<0.0001) than SCC patients. Bilharzial eggs were found in 61% of SCC vs 46% of SqD (p=0.001). Median follow up period for SCC was 3.9 ( 0-12.4) versus 2 years (0-12) for SqD. During this period, 49 (15.4%) patients with SCC recurred locally and 20 (6.3%) recurred distally. Meanwhile, among SqD group 41 patients (18.4%) developed distant metastasis and 47 (21. 2%) experienced local recurrence. The estimated 5-year CSS was 77% and 59.8 % for SCC and SqD respectively (Fig.1) (Log rank <0.0001). In patients with SCC, Cox regression models identified higher T-stage (HR 2.3, 95% CI 1.3-3.9, P= 0.002) and preoperative anaemia (HR 1.7, 95% CI 1.035-2.8, P= 0.036) to be significantly associated with worse CSS. In patients with SqD, higher T-stage (HR 1.7, 95% CI 1.06-3, P= 0.028) and nodal metastasis (HR 2.2, 95% CI 1.3-3.5, P = 0.002) were associated with reduced CSS. CONCLUSIONS Patient with SCC had better 5-year CSS in comparison to SqD. The higher rate of extravesical disease and lymph node metastasis in SqD patients is indicative of aggressive behavior of this histologic type. © 2017FiguresReferencesRelatedDetails Volume 197Issue 4SApril 2017Page: e778-e779 Advertisement Copyright & Permissions© 2017MetricsAuthor Information Mahmoud Laymon More articles by this author Ahmed Mansour More articles by this author Mohamed M. Elsaadany More articles by this author Ahmed Mosbah More articles by this author Shaaban AA More articles by this author Hassan Abol-enein More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...