MP63-07 CHARACTERIZATION OF LOW AMPLITUDE RHYTHMIC CONTRACTIONS DURING URODYNAMICS

You have accessJournal of UrologyUrodynamics/Lower Urinary Tract Dysfunction/Female Pelvic Medicine: Incontinence: Evaluation (Urodynamic Testing)1 Apr 2017MP63-07 CHARACTERIZATION OF LOW AMPLITUDE RHYTHMIC CONTRACTIONS DURING URODYNAMICS Zachary Cullingsworth, Brooks Kelly, William Simmons, Andrew Colhoun, Anna Nagle, Randy Vince, John Speich, and Adam Klausner Zachary CullingsworthZachary Cullingsworth More articles by this author , Brooks KellyBrooks Kelly More articles by this author , William SimmonsWilliam Simmons More articles by this author , Andrew ColhounAndrew Colhoun More articles by this author , Anna NagleAnna Nagle More articles by this author , Randy VinceRandy Vince More articles by this author , John SpeichJohn Speich More articles by this author , and Adam KlausnerAdam Klausner More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2017.02.1959AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Human detrusor smooth muscle (DSM) can exhibit low amplitude rhythmic contractions (LARC) which may contribute to overactive bladder (OAB) in some patients. The aim of this study was to develop an objective method to identify LARC during urodynamics (UD), categorize patients with significant LARC, and potentially begin to characterize a LARC-mediated OAB/detrusor overactivity subtype. METHODS An algorithm was developed to analyze UD filling data in low volume (1st 410 seconds) and high volume (final 410s) regions. Fast Fourier Transform (FFT) analysis identified the frequency (F) in the 1-6 cycle/min range associated with the maximum amplitude of the vesical pressure (Pves) in each region (Fig 1). A patient-specific range of interest corresponding to F ± 0.5 cycles/min was determined. Pves and Pabd amplitudes were analyzed separately to identify both significant (higher than average) and independent (distinct from Pabd) Pves signals. To be significant, Pves amplitude must be > 1.35 standard deviations (SD) above average Pves amplitude. To be independent, the Pabd amplitude must be < 1.35 SD above the average Pabd amplitude. SD of 1.35 was chosen using an iterative process in 0.05 SD increments to identify the maximum number of significant and independent signals. RESULTS This algorithm was used to retrospectively analyze 43 consecutive UD studies which included 25 (14 neurogenic, 11 idiopathic) with detrusor overactivity (58%). The average age of the entire group was 55±2 years and included 14 men and 29 women. FFT analysis identified a significant and independent Pves signal in 12/43 patients (28%) of which 8/12 (67%, 5 neurogenic, 3 idiopathic) had detrusor overactivity. The average age of patients with significant and independent signals was 54±5 years and included 6 men and 6 women. CONCLUSIONS Analysis of LARC during UD testing identified a subset of patients with a significant and independent slow wave frequency in Pves. Further refinements of this technique may help identify subsets of individuals with LARC-mediated OAB/detrusor overactivity. © 2017FiguresReferencesRelatedDetails Volume 197Issue 4SApril 2017Page: e838 Advertisement Copyright & Permissions© 2017MetricsAuthor Information Zachary Cullingsworth More articles by this author Brooks Kelly More articles by this author William Simmons More articles by this author Andrew Colhoun More articles by this author Anna Nagle More articles by this author Randy Vince More articles by this author John Speich More articles by this author Adam Klausner More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...