MP09-06 ADMINISTRATION OF DAILY 5MG TADALAFIL IMPROVES NOT ONLY LOWER URINARY TRACT SYMPTOMS BUT ALSO VESSEL ENDOTHELIAL FUNCTION IN PATIENTS WITH BENIGN PROSTATIC HYPERPLASIA

You have accessJournal of UrologyBenign Prostatic Hyperplasia: Medical & Non-surgical Therapy1 Apr 2017MP09-06 ADMINISTRATION OF DAILY 5MG TADALAFIL IMPROVES NOT ONLY LOWER URINARY TRACT SYMPTOMS BUT ALSO VESSEL ENDOTHELIAL FUNCTION IN PATIENTS WITH BENIGN PROSTATIC HYPERPLASIA Toshiyasu Amano, Takahiro Kishikage, and Tetsuya Imao Toshiyasu AmanoToshiyasu Amano More articles by this author , Takahiro KishikageTakahiro Kishikage More articles by this author , and Tetsuya ImaoTetsuya Imao More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2017.02.314AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Tadalafil is a promising phosphodiesterase (PDE) 5 inhibitor for erectile dysfunction (ED) treatment. Daily low dose (5mg) of tadalafil is also applied for the treatment of male lower urinary tract symptoms (LUTS) associated with benign prostate hyperplasia (BPH). PDE5 inhibitors induce relaxation of smooth muscle cells in urethra, prostate, bladder neck and blood vessels. The aim of this study is to investigate the efficacy of tadalafil for vessels endothelial function, besides male LUTS symptoms in patients with BPH. METHODS The Institutional Review Board (IRB) had approved this clinical study, and informed consents have been obtained from 70 BPH patients. (1) The male LUTS parameters such as international prostate symptom score (IPSS), overactive bladder symptom score (OABSS), residual urine (RU) were compared before and 1month, 3 months, 6 months, 12months after daily 5mg tadalafil treatment. (2) In addition, erectile function and vessels endothelial function were evaluated by sexual health inventory for men (SHIM) score, brachial-ankle pulse wave velocity (baPWV) and ankle brachial index (ABI) before and 3 months, 6 months, 12months after tadalafil treatment. RESULTS The mean age of 70 patients were 65.7+/-11.6 years old. The prostate size was 30.2+/-22.7 ml. (1) All male LUTS parameters including total IPSS, OABSS and RU were significantly improved 1 to 12 months after tadalafil administration. (2) Furthermore, SHIM score significantly improved after 3 months. baPWV is a measure of arterial stiffness and a marker of vascular damages. Generally, higher baPWV means that the vessels are less elasticity, and baPWV data increase according to aging. The results of baPWV significantly improved from 3 to 6 months (p<0.01) and the same levels at 12 months compared with baseline (Figure). ABI is an indicator of arterial sclerosis and arterial sclerosis is diagnosed when ABI is less than 0.9. In this study, ABI was not significantly changed by tadalafil. CONCLUSIONS Tadalafil is effective not only for male LUTS but also ED. Furthermore, tadalafil improves baPWV data, which means higher vessels elasticity has been obtained. The major new finding of this study is that tadalafil had a potency to improve vessels endothelial dysfunction in patients with BPH. © 2017FiguresReferencesRelatedDetails Volume 197Issue 4SApril 2017Page: e101 Advertisement Copyright & Permissions© 2017MetricsAuthor Information Toshiyasu Amano More articles by this author Takahiro Kishikage More articles by this author Tetsuya Imao More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...