MP19-15 THE RELATIONSHIP BETWEEN HYPERURICEMIA AND URIC-ACID STONE FOR RENAL FUNCTION DETERIORATION: A POPULATION-BASED ANALYSIS

You have accessJournal of UrologyStone Disease: Basic Research & Pathophysiology II1 Apr 2017MP19-15 THE RELATIONSHIP BETWEEN HYPERURICEMIA AND URIC-ACID STONE FOR RENAL FUNCTION DETERIORATION: A POPULATION-BASED ANALYSIS Toshikazu Tanaka, Shingo Hatakeyama, Yuriko Terayama, Fumitada Saitoh, Hisao Saitoh, Yasuhiro Hashimoto, Takuya Koie, and Chikara Ohyama Toshikazu TanakaToshikazu Tanaka More articles by this author , Shingo HatakeyamaShingo Hatakeyama More articles by this author , Yuriko TerayamaYuriko Terayama More articles by this author , Fumitada SaitohFumitada Saitoh More articles by this author , Hisao SaitohHisao Saitoh More articles by this author , Yasuhiro HashimotoYasuhiro Hashimoto More articles by this author , Takuya KoieTakuya Koie More articles by this author , and Chikara OhyamaChikara Ohyama More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2017.02.3257AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Although both hyperuricemia and uric-acid (UA) stone are potential risk factors for Chronic Kidney Disease (CKD), it remains unclear which factor has much more worse effects on renal function. We accessed the influence of hyperuricemia on impaired renal function in patients with UA stone components in comparison with community-dwelling population. METHODS Between 2010 and 2014, we treated 1793 consecutive patients with urolithiasis in our hospital, and identified stone components available 473 patients. Of those, 123 patients with UA stone were included in the present study. Age, sex, and serum UA concentration adjusted control subjects were selected from 3089 community-dwelling population in each group by propensity-score matching (2:1). Subjects were divided into two groups; hyperuricemia or non-hyperuricemia groups according to the serum UA concentrations (UA-low: < 7.0 or UA-high: =7.0 mg/mL). We compared renal function between the UA stone and control subjects in each group. The renal function was evaluated as estimated glomerular filtration rate (eGFR). The independent risk factor for impaired renal function were investigated by multivariate logistic regression analysis. RESULTS We selected pair-matched 166 control subjects and 83 UA stone patients for serum UA-low group. Similarly, 68 control subjects and 34 UA stone patients for serum UA-high group. UA stone patients had significantly lower in eGFR (P<0.01) compared with control subjects regardless of serum UA concentrations. Multivariate logistic regression analysis revealed that age, past-history of cardiovascular disease, serum UA, and stone former were significant factors for stage 3 CKD. UA stone component had 3-fold chance to develop stage 3 CKD than serum UA concentration. CONCLUSIONS Uric acid stone components may strongly influence on renal function deterioration than hyperuricemia. © 2017FiguresReferencesRelatedDetails Volume 197Issue 4SApril 2017Page: e235-e236 Advertisement Copyright & Permissions© 2017MetricsAuthor Information Toshikazu Tanaka More articles by this author Shingo Hatakeyama More articles by this author Yuriko Terayama More articles by this author Fumitada Saitoh More articles by this author Hisao Saitoh More articles by this author Yasuhiro Hashimoto More articles by this author Takuya Koie More articles by this author Chikara Ohyama More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...