Gliostry (Glioblastoma Registry) Of The Aino (Italian Association Of Neuro-Oncology): Analysis Of Factors Influencing Survival In Glioblastoma Patients Receiving The Nitrosourea Fotemustine At First Relapse Following Stupp Regimen.

2054 Background: patients with glioblastoma failing radiotherapy plus temozolomide are treated in Europe with nitrosourea-based regimens, but factors influencing survival are not entirely known.We investigated the factors influencing survival in a large cohort of Italian glioblastoma patients who received the nitrosourea fotemustine (FTM) at first relapse following the Stupp regimen. Methods: survival data and information on demographics, clinical, radiological, molecular and treatments factors were collected in 34 Italian Institutions. PFS and OS curves were constructed using the Kaplan-Meier method and both univariate and multivariate analysis were performed . Results: Since 2005, 921 (587 M 334 F, median age 56 yrs) patients were enrolled , and up to date 897 are evaluable. Median PFS following FTM was 103 days. Factors of prognostic significance in univariate analysis were: MGMT methylation (129 d methylated vs 90 d unmethylated tumors, p u003c 0.001) and association with bevacizumab (148 d the associatio...