PD56-07 CAN FOCAL THERAPY IMPACT ON PERIOPERATIVE, ONCOLOGICAL AND FUNCTION OUTCOMES IN MEN UNDERWENT FOCAL THERAPY SALVAGE ROBOTIC-ASSISTED RADICAL PROSTATECTOMY? A RETROSPECTIVE MATCHED-PAIR COMPARATIVE STUDY

You have accessJournal of UrologyProstate Cancer: Localized: Ablative Therapy II1 Apr 2017PD56-07 CAN FOCAL THERAPY IMPACT ON PERIOPERATIVE, ONCOLOGICAL AND FUNCTION OUTCOMES IN MEN UNDERWENT FOCAL THERAPY SALVAGE ROBOTIC-ASSISTED RADICAL PROSTATECTOMY? A RETROSPECTIVE MATCHED-PAIR COMPARATIVE STUDY Igor Nunes-Silva, Eric Barret, Victor Srougi, Mohammed Baghdadi, Silvia Garcia-Barreras, Paolo Capogrosso, Gregorie Rembeyo, Ariê Carneiro, Rafael Sanchez-Salas, François Rozet, Marc Galiano, and Xavier Cathelineau Igor Nunes-SilvaIgor Nunes-Silva More articles by this author , Eric BarretEric Barret More articles by this author , Victor SrougiVictor Srougi More articles by this author , Mohammed BaghdadiMohammed Baghdadi More articles by this author , Silvia Garcia-BarrerasSilvia Garcia-Barreras More articles by this author , Paolo CapogrossoPaolo Capogrosso More articles by this author , Gregorie RembeyoGregorie Rembeyo More articles by this author , Ariê CarneiroAriê Carneiro More articles by this author , Rafael Sanchez-SalasRafael Sanchez-Salas More articles by this author , François RozetFrançois Rozet More articles by this author , Marc GalianoMarc Galiano More articles by this author , and Xavier CathelineauXavier Cathelineau More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2017.02.2596AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Salvage surgery is an option for recurrent prostate cancer(PCa) after focal therapy(FT). This is the first study to assess the impact of FT on surgical outcomes comparing salvage robotic-assisted radical prostatectomy(S-RARP) versus primary-RARP(P-RARP). We aimed to compare the impact of FT on perioperative, oncological and functional outcomes in men underwent S-RARP versus P-RARP. METHODS Prospective data of 2775 men underwent RARP for localized PCa from 2000 to 2016 were reviewed. Twenty-five men underwent S-RARP after FT failure(S-RARP group). Total 2750 underwent RARP as primary treatment. Matched-pair 1:2 selection of 44 out of 2750 patients by age, IPSS and IIEF5 defined P-RARP group. Primary endpoint was between-groups differences on functional outcomes. Secondary endpoint was oncological data. p<0.05 was significant. RESULTS Surgical time, transfusion and complication rates were comparable(p≥0.05). Rates of continence probability[49.5%(SE 0.13) versus 62.4%(SE 0.08), p=0.8 and 73%(SE 0.14) versus 76.5%(SE 0.07), p=0.8, at 1 and 2 years, respectively] and the chance for achieving continence[HR 1.062, 95%CI 0.54-2.08, p=0.861] were comparable between-groups. Potency recovery was significant lower on S-RARP at 1 year follow-up[3±2 versus 9.22±6.55, p=0.008]. S-RARP showed significant lower rates of cumulative BCR-free survival probability[67.6%(SE 0.12) versus 95.1%(SE 0.03), p=0.001 and 56,3%(SE 0.15) versus 92,4%(SE 0.04), p=0.001, at 1 and 2 years, respectively]. S-RARP presented significant increased risk of BCR[HR 4.8, 95%CI 1.67-13.76, p=0.004]. Upstaging was an independent predictor factor for BCR on S-RARP[HR 14.65, 95%CI 1.46-146.37, p=0.022]. CONCLUSIONS Salvage-RARP following FT failure is feasible and safe with acceptable complications rates. Patients assigned to FT should be previously advised about lower erectile recovery rates in case of a salvage surgery. Urologists may be warned about the risk of undertreatment in patients presenting failure along FT follow-up. © 2017FiguresReferencesRelatedDetails Volume 197Issue 4SApril 2017Page: e1118 Advertisement Copyright & Permissions© 2017MetricsAuthor Information Igor Nunes-Silva More articles by this author Eric Barret More articles by this author Victor Srougi More articles by this author Mohammed Baghdadi More articles by this author Silvia Garcia-Barreras More articles by this author Paolo Capogrosso More articles by this author Gregorie Rembeyo More articles by this author Ariê Carneiro More articles by this author Rafael Sanchez-Salas More articles by this author François Rozet More articles by this author Marc Galiano More articles by this author Xavier Cathelineau More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...