Prognostic Implications Of Serum Crosslinked-N-Terminal Telopeptide Of Type I Collagen (Ntx) For Patients With Initial Prostate Carcinoma.

e16030 Background: NTx is a metabolite of type I collagen, the main constituent of bone matrix, which has been previously shown to be increased in patients with bone metastasis. We wanted to evaluate NTx role in sample PCa patients at diagnosis when most of them have no overt bone involvement. Methods: Men with a histologic diagnosis of PCa at diagnosis were included. Serum Ntx was measured serially every 3 months up to two years by ELISA with the osteomark NTx Serum kit. Results: 55 PCa patients with a median age of 67 years (51 – 83), 86% with stage I, 4% with stage II, 2% with stage III and 10% with stage IV were included. At entry median NTx was of 14.65 nM and it did not correlate with age, Gleason score or PSA but we observed a significant direct correlation with stage (p = 0.0094). With a median follow up of 23 months, at diagnosis, Seum Ntx correlated significantly with biochemical recurrence (p = 0.012) as did Gleason score (p = 0.00056), Stage (p = 0.012) and PSA (p u003c 0.0001). By multivariate an...