(173) - Human Right Ventricular Myofilaments Exhibit Directionally Opposite Changes in Maximal Force and Calcium Sensitivity in Systemic Sclerosis-Associated versus Idiopathic Pulmonary Arterial Hypertension

Steven Hsu,Jonathan A. Kirk,Christopher J. Mullin,M. Mukherjee,Todd M. Kolb,Rachel Damico,Stephen C. Mathai,Ami A. Shah,Frederick M. Wigley,Kenneth B. Margulies,Paul M. Hassoun,Ryan J. Tedford,David A. Kass

Journal of Heart and Lung Transplantation（2017）

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摘要

Right ventricular (RV) contractile function has been shown to be significantly worse in systemic sclerosis-associated pulmonary arterial hypertension (SSc-PAH) versus idiopathic PAH (IPAH), in concordance with worsened SSc-PAH outcomes. Whether this involves underlying myofilament differences remains unknown.

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关键词

arterial hypertension,pulmonary,calcium sensitivity,sclerosis-associated

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