Assessment Of Age As Its Own Risk Factor In Aml
JOURNAL OF CLINICAL ONCOLOGY(2012)
Abstract
6610 Background: Patients’ age is an important issue in treatment decisions for AML, while its role in this disease remains poorly explained. Methods: In the AMLCG 1999 trial 1223 patients (pts) were 16-59y and 1470 pts were 60-85y of age. Their treatment was randomized between TAD-HAM vs HAM-HAM induction (TAD, standard dose thioguanine, cytarabine, daunorubicin 60mg/m² x 3; HAM, high-dose cytarabine 3g/m² x 6, mitoxantrone 10mg/m² x 3), TAD consolidation and monthly maintenance vs autologous SCT, any chemotherapy + vs - G-CSF priming. All randomization was done upfront. Pts of u003c60y received routine double induction and full dose HAM while pts of 60+y preferentially received only one course induction and HAM at 1g instead of 3g cytarabine /m² x 6. Results: With little differences according randomizations, pts u003c60y and 60+y achieved a complete remission rate (CR) of 70.2% and 53.5% (pu003c.001), overall survival (OS) at 5y of 41.3% and 12.9% (pu003c.001) and a relapse rate (RR) of 49.0 and 72.0% (pu003c.001). We also...
MoreTranslated text
Key words
AML
AI Read Science
Must-Reading Tree
Example
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
Generate MRT to find the research sequence of this paper
Chat Paper
Summary is being generated by the instructions you defined